I was living in a studio apartment in Allston, Massachusetts, which is sort of like a student ghetto of cheap apartments. Evan Dando was sort of crashing there. He had nothing to do with it, but I just remember he was around. And I was trying to write something catchy and accessible, but not in a crass, commercial way. I just came up with those four chords that are the verse, and then it sort of ended up not having a chorus.
I've always been in this sort of perpetual state of existential longing. I feel like something's missing. I almost feel like I have a twin who died at birth but no one ever told me that the twin existed. And with this song, I was trying to explore the idea of a sister who I never had. In the beginning, that seemed like a really nice idea. I had two brothers, but I never had a sister. But then the song ended up being kind of sad. It was more of a longing for a sister who was never nice to me, or a relationship lacking the things that I wanted from it.
SPIN has a lengthy article revisiting 1993's My Sister featuring quotes from many including members of The Juliana Hatfield Three and, yes, the Violent Femmes and the Del Fuegos.
You don't want to miss this one.